Selected publications

Insufficient treatment of severe depression in neuromyelitis optica spectrum disorder Velina S. Chavarro, Maureen A. Mealy, Alexandra Simpson, Anna Lacheta, Florence Pache, Klemens Ruprecht, Stefan M. Gold, Friedemann Paul, Alexander Ulrich Brandt, Michael Levy, Published online October 24, 2016 doi: http:/​/​dx.​doi.​org/​10.​1212/​NXI.​0000000000000286

Reliability of Intra-Retinal Layer Thickness Estimates. Oberwahrenbrock T, Weinhold M, Mikolajczak J, Zimmermann H, Paul F, Beckers I, Brandt AU. PLoS One. 2015 Sep 8;10(9):e0137316. doi: 10.1371/journal.pone.0137316.

Retinal pathology in Susac syndrome detected by spectral-domain optical coherence tomography. Ringelstein M, Albrecht P, Kleffner I, Bühn B, Harmel J, Müller AK, Finis D, Guthoff R, Bergholz R, Duning T, Krämer M, Paul F, Brandt A, Oberwahrenbrock T, Mikolajczak J, Wildemann B, Jarius S, Hartung HP, Aktas O, Dörr J. Neurology. 2015 Aug 18;85(7):610-8. doi: 10.1212/WNL.0000000000001852.

Ultrahigh field MRI in clinical neuroimmunology: a potential contribution to improved diagnostics and personalised disease management. Sinnecker T, Kuchling J, Dusek P, Dörr J, Niendorf T, Paul F, Wuerfel J. EPMA J. 2015 Aug 27;6(1):16. doi: 10.1186/s13167-015-0038-y.

Low 25-hydroxyvitamin D, but not the bioavailable fraction of 25-hydroxyvitamin D, is a risk factor for multiple sclerosis. Behrens JR, Rasche L, Gieß RM, Pfuhl C, Wakonig K, Freitag E, Deuschle K, Bellmann-Strobl J, Paul F, Ruprecht K, Dörr J. Eur J Neurol. 2015 Jul 28. doi: 10.1111/ene.12788.

Magnetic Resonance Phase Alterations in Multiple Sclerosis Patients with Short and Long Disease Duration. Bozin I, Ge Y, Kuchling J, Dusek P, Chawla S, Harms L, Ruprecht K, Niendorf T, Paul F, Kister I, Sinnecker T, Wuerfel J. PLoS One. 2015 Jul 17;10(7):e0128386. doi: 10.1371/journal.pone.0128386.

Pushing the boundaries of neuromyelitis optica: Does antibody make the disease? Kister I, Paul F. Neurology. 2015 Jul 14;85(2):118-9. doi: 10.1212/WNL.0000000000001749.

Altered basal ganglia functional connectivity in multiple sclerosis patients with fatigue. Finke C, Schlichting J, Papazoglou S, Scheel M, Freing A, Soemmer C, Pech LM, Pajkert A, Pfüller C, Wuerfel JT, Ploner CJ, Paul F, Brandt AU. Mult Scler. 2015 Jun;21(7):925-34. doi: 10.1177/1352458514555784.

Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography. Bennett JL, de Seze J, Lana-Peixoto M, Palace J, Waldman A, Schippling S, Tenembaum S, Banwell B, Greenberg B, Levy M, Fujihara K, Chan KH, Kim HJ, Asgari N, Sato DK, Saiz A, Wuerfel J, Zimmermann H, Green A, Villoslada P, Paul F; GJCF-ICC&BR. Mult Scler. 2015 May;21(6):678-88. doi: 10.1177/1352458514567216.

MRI characteristics of neuromyelitis optica spectrum disorder: an international update. Kim HJ, Paul F, Lana-Peixoto MA, Tenembaum S, Asgari N, Palace J, Klawiter EC, Sato DK, de Seze J, Wuerfel J, Banwell BL, Villoslada P, Saiz A, Fujihara K, Kim SH; Guthy-Jackson Charitable Foundation NMO International Clinical Consortium & Biorepository. Neurology. 2015 Mar 17;84(11):1165-73. doi: 10.1212/WNL.0000000000001367.

Metabolic response to epigallocatechin-3-gallate in relapsing-remitting multiple sclerosis: a randomized clinical trial. Mähler A, Steiniger J, Bock M, Klug L, Parreidt N, Lorenz M, Zimmermann BF, Krannich A, Paul F, Boschmann M. Am J Clin Nutr. 2015 Mar;101(3):487-95. doi: 10.3945/ajcn.113.075309.

Structural Hippocampal Damage Following Anti-N-Methyl-D-Aspartate Receptor Encephalitis. Finke C, Kopp UA, Pajkert A, Behrens JR, Leypoldt F, Wuerfel JT, Ploner CJ, Prüss H, Paul F. Biol Psychiatry. 2015 Feb 26. pii: S0006-3223(15)00149-3. doi: 10.1016/j.biopsych.2015.02.024.

Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning--an ultrahigh-field MR pilot study. Sinnecker T, Oberwahrenbrock T, Metz I, Zimmermann H, Pfueller CF, Harms L, Ruprecht K, Ramien C, Hahn K, Brück W, Niendorf T, Paul F, Brandt AU, Dörr J, Wuerfel J. Eur Radiol. 2015 Jan;25(1):122-31. doi: 10.1007/s00330-014-3358-8.

Retinal nerve fibre layer thickness correlates with brain white matter damage in multiple sclerosis: a combined optical coherence tomography and diffusion tensor imaging study. Scheel M, Finke C, Oberwahrenbrock T, Freing A, Pech LM, Schlichting J, Sömmer C, Wuerfel J, Paul F, Brandt AU. Mult Scler. 2014 Dec;20(14):1904-7. doi: 10.1177/1352458514535128.

Aquaporin-4 antibody testing: direct comparison of M1-AQP4-DNA-transfected cells with leaky scanning versus M23-AQP4-DNA-transfected cells as antigenic substrate. Jarius S, Paul F, Fechner K, Ruprecht K, Kleiter I, Franciotta D, Ringelstein M, Pache F, Aktas O, Wildemann B. J Neuroinflammation. 2014 Jul 29;11:129. doi: 10.1186/1742-2094-11-129.

Dynamic formation of macular microcysts independent of vitreous traction changes. Brandt AU, Oberwahrenbrock T, Kadas EM, Lagrèze WA, Paul F. Neurology. 2014 Jul 1;83(1):73-7. doi: 10.1212/WNL.0000000000000545.

Neuromyelitis optica: clinical features, immunopathogenesis and treatment. Jarius S, Wildemann B, Paul F. Clin Exp Immunol. 2014 May;176(2):149-64. doi: 10.1111/cei.12271.

Clinical, paraclinical and serological findings in Susac syndrome: an international multicenter study. Jarius S, Kleffner I, Dörr JM, Sastre-Garriga J, Illes Z, Eggenberger E, Chalk C, Ringelstein M, Aktas O, Montalban X, Fechner K, Stöcker W, Ringelstein EB, Paul F, Wildemann B.  J Neuroinflammation. 2014 Mar 8;11:46. doi: 10.1186/1742-2094-11-46.

Update on the diagnosis and treatment of neuromyelitis optica: recommendations of the Neuromyelitis Optica Study Group (NEMOS). Trebst C, Jarius S, Berthele A, Paul F, Schippling S, Wildemann B, Borisow N, Kleiter I, Aktas O, Kümpfel T; Neuromyelitis Optica Study Group (NEMOS). J Neurol. 2014 Jan;261(1):1-16. doi: 10.1007/s00415-013-7169-7.

Retinal ganglion cell and inner plexiform layer thinning in clinically isolated syndrome. Oberwahrenbrock T, Ringelstein M, Jentschke S, Deuschle K, Klumbies K, Bellmann-Strobl J, Harmel J, Ruprecht K, Schippling S, Hartung HP, Aktas O, Brandt AU, Paul F. Mult Scler. 2013 Dec;19(14):1887-95. doi: 10.1177/1352458513489757.

Functional and structural brain changes in anti-N-methyl-D-aspartate receptor encephalitis. Finke C, Kopp UA, Scheel M, Pech LM, Soemmer C, Schlichting J, Leypoldt F, Brandt AU, Wuerfel J, Probst C, Ploner CJ, Prüss H, Paul F. Ann Neurol. 2013 Aug;74(2):284-96. doi: 10.1002/ana.23932.

Characteristics of Susac syndrome: a review of all reported cases. Dörr J, Krautwald S, Wildemann B, Jarius S, Ringelstein M, Duning T, Aktas O, Ringelstein EB, Paul F, Kleffner I. Nat Rev Neurol. 2013 Jun;9(6):307-16. doi: 10.1038/nrneurol.2013.82.

Hope for a rare disease: eculizumab in neuromyelitis optica. Paul F. Lancet Neurol. 2013 Jun;12(6):529-31. doi: 10.1016/S1474-4422(13)70089-9.

What went wrong? The flawed concept of cerebrospinal venous insufficiency. Valdueza JM, Doepp F, Schreiber SJ, van Oosten BW, Schmierer K, Paul F, Wattjes MP. J Cereb Blood Flow Metab. 2013 Feb 27. doi: 10.1038/jcbfm.2013.31. Epub ahead of print.

Higher macular volume in patients with MS receiving fingolimod: positive outcome or side effect? Dinkin M, Paul F. Neurology. 2013 Jan 8;80(2):128-9. doi: 10.1212/WNL.0b013e31827ccf4a.

Failure of natalizumab to prevent relapses in neuromyelitis optica. Kleiter I, Hellwig K, Berthele A, Kümpfel T, Linker RA, Hartung HP, Paul F, Aktas O; Neuromyelitis Optica Study Group. Arch Neurol. 2012 Feb;69(2):239-45. doi: 10.1001/archneurol.2011.216.

Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases. Mähler A, Mandel S, Lorenz M, Ruegg U, Wanker EE, Boschmann M, Paul F. EPMA J. 2013 Feb 18;4(1):5

Can we prevent or treat multiple sclerosis by individualized  vitamin D supply? Dörr J, Döring A, Paul F. EPMA J. 2013 Jan 29;4(1):4

Dynamics of saccade parameters in multiple sclerosis patients with fatigue. Finke C, Pech LM, Sömmer C, Schlichting J, Stricker S, Endres M, Ostendorf F, Ploner CJ, Brandt AU, Paul F. J Neurol. 2012 Dec;259(12):2656-63.

Lesion morphology at 7 Tesla MRI differentiates Susac syndrome from multiple sclerosis. Wuerfel J, Sinnecker T, Ringelstein EB, Jarius S, Schwindt W, Niendorf T, Paul F, Kleffner I, Dörr J. Mult Scler. 2012 Nov;18(11):1592-9.

Vitamin D and multiple sclerosis : The role for risk of disease and treatment. Döring A, Paul F, Dörr J. Nervenarzt. 2012 Oct 7. 

Optic neuritis interferes with optical coherence tomography and magnetic resonance imaging correlations. Zimmermann H, Freing A, Kaufhold F, Gaede G, Bohn E, Bock M, Oberwahrenbrock T, Young KL, Dörr J, Wuerfel JT, Schippling S, Paul F, Brandt AU. Mult Scler. 2012 Aug 30. PubMed PMID: 22936335

Distinct lesion morphology at 7-T MRI differentiates neuromyelitis optica from multiple sclerosis. Sinnecker T, Dörr J, Pfueller CF, Harms L, Ruprecht K, Jarius S, Brück W, Niendorf T, Wuerfel J, Paul F. Neurology. 2012 Aug 14;79(7):708-14.

Periventricular venous density in multiple sclerosis is inversely associated with T2 lesion count: a 7 Tesla MRI study. Sinnecker T, Bozin I, Dörr J, Pfueller CF, Harms L, Niendorf T, Brandt AU, Paul F, Wuerfel J. Mult Scler. 2012

Expert recommendations to personalization of medical approaches in treatment of multiple sclerosis: an overview of family planning and pregnancy. Borisow N, Döring A, Pfueller CF, Paul F, Dörr J, Hellwig K. EPMA J. 2012 Jun 22;3(1):9.

Multiple sclerosis lesions and irreversible brain tissue damage: a comparative ultrahigh-field strength magnetic resonance imaging study. Sinnecker T, Mittelstaedt P, Dörr J, Pfueller CF, Harms L, Niendorf T, Paul F, Wuerfel J. Arch Neurol. 2012 Jun;69(6):739-45.

Fatigue in multiple sclerosis: a diagnostic and therapeutic challenge. Paul F, Veauthier C. Expert Opin Pharmacother. 2012 Apr;13(6):791-3.

Efficacy of vitamin D supplementation in multiple sclerosis (EVIDIMS Trial): study protocol for a randomized controlled trial. Dörr J, Ohlraun S, Skarabis H, Paul F. Trials. 2012 Feb 8;13:15. PubMed PMID: 22316314; PubMed Central PMCID: PMC3298796

Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients. Jarius S, Ruprecht K, Wildemann B, Kuempfel T, Ringelstein M, Geis C, Kleiter I, Kleinschnitz C, Berthele A, Brettschneider J, Hellwig K, Hemmer B, Linker RA, Lauda F, Mayer CA, Tumani H, Melms A, Trebst C, Stangel M, Marziniak M, Hoffmann F, Schippling S, Faiss JH, Neuhaus O, Ettrich B, Zentner C, Guthke K, Hofstadt-van Oy U, Reuss R, Pellkofer H, Ziemann U, Kern P, Wandinger KP, Bergh FT, Boettcher T, Langel S, Liebetrau M, Rommer PS, Niehaus S, Münch C, Winkelmann A, Zettl U UK, Metz I, Veauthier C, Sieb JP, Wilke C, Hartung HP, Aktas O, Paul F. J Neuroinflammation. 2012 Jan 19;9:14. PubMed PMID: 22260418; PubMed Central PMCID: PMC3283476

Retinal damage in multiple sclerosis disease subtypes measured by high-resolution optical coherence tomography. Oberwahrenbrock T, Schippling S, Ringelstein M, Kaufhold F, Zimmermann H, Keser N, Young KL, Harmel J, Hartung HP, Martin R, Paul F, Aktas O, Brandt AU. Mult Scler Int. 2012;2012:530305. PubMed PMID: 22888431; PubMed Central PMCID: PMC3410317

Patterns of retinal damage facilitate differential diagnosis between Susac syndrome and MS. Brandt AU, Zimmermann H, Kaufhold F, Promesberger J, Schippling S, Finis D, Aktas O, Geis C, Ringelstein M, Ringelstein EB, Hartung HP, Paul F, Kleffner I, Dörr J. PLoS One. 2012;7(6):e38741. PubMed PMID: 22701702; PubMed Central PMCID: PMC3372471

Exercise in multiple sclerosis – an integral component of disease management. Döring A, Pfueller CF, Paul F, Dörr J. EPMA J. 2011 Dec 24;3(1):2. PubMed PMID: 22738091; PubMed Central PMCID: PMC3375103

Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography. Brandt AU, Oberwahrenbrock T, Ringelstein M, Young KL, Tiede M, Hartung HP, Martin R, Aktas O, Paul F, Schippling S. Brain. 2011

Association of Retinal and Macular Damage with Brain Atrophy in Multiple Sclerosis. Dörr J, Wernecke KD, Bock M, Gaede G, Wuerfel JT, Pfueller CF, Bellmann-Strobl J, Brandt AU, Paul F. PLoS ONE 2011 

Metabolic changes in the visual cortex are linked to retinal nerve fiber layer thinning .in multiple sclerosis. Pfueller CF, Brandt AU, Schubert F, Bock M, Walaszek B, Waiczies H, Thomas Schwenteck T, Dörr J, Bellmann-Strobl J, Mohr C, Weinges-Evers N, Ittermann B, Wuerfel JT, Paul F. PLoS ONE 2011 

Correlation of self-assessed fatigue and alertness in multiple sclerosis. Weinges-Evers N, Brandt AU, Bock M, Pfueller CF, Dörr J, Bellmann-Strobl J, Scherer P, Urbanek C, Boers C, Ohlraun S, Zipp F, Paul F. Mult Scler. 2010 

Time domain and spectral domain optical coherence tomography in multiple sclerosis: a comparative cross-sectional study. Bock M, Brandt AU, Dörr J, Pfueller CF, Ohlraun S, Zipp F, Paul F. Mult Scler. 2010 

Attention Network Test reveals alerting network dysfunction in multiple sclerosis. Urbanek C, Weinges-Evers N, Bellmann-Strobl J, Bock M, Dörr J, Hahn E, Neuhaus AH, Opgen-Rhein C, Ta TM, Herges K, Pfueller CF, Radbruch H, Wernecke KD, Ohlraun S, Zipp F, Dettling M, Paul F. Mult Scler. 2010 

Encephalopathy, visual disturbance and hearing loss-recognizing the symptoms of Susac syndrome. Dörr J, Radbruch H, Bock M, Wuerfel J, Brüggemann A, Wandinger KP, Zeise D, Pfueller CF, Zipp F, Paul F. Nat Rev Neurol. 2009 

Poor PASAT performance correlates with MRI contrast enhancement in multiple sclerosis. Bellmann-Strobl J, Wuerfel J, Aktas O, Dörr J, Wernecke KD, Zipp F, Paul F. Neurology. 2009