New Junior Groups
As part of our commitment to provide opportunities for early career researchers, NeuroCure will establish several new junior research groups in cooperation with our partner institutions during the current funding period.
New groups established so far include:
Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE)
The Neurocircuit Development and Function (NDF) group is engaged in understanding how neural circuits involved in the control of energy homeostasis develop and function within complex networks in the brain. Specifically, the team wants to understand how maternal nutrition and altered maternal metabolism can negatively impact the proper formation and function of these brain circuits, resulting in the potential for an earlier onset of brain-related diseases. This work is performed using rodent model systems to target the function of specific neuronal systems to better understand their role in metabolism and behavior.
Berlin Institute of Health (BIH)
Many neurological diseases are characterized by rapid state shifts, health deteriorations, relapses and fluctuations. The current approach to monitoring and treating these diseases is limited in the inability to adequately capture these often complex, nonlinear dynamic aspects. Development of more predictive diagnostics for timely treatments, personalized to the patient’s respective clinical state demands a more comprehensive understanding of the health-disease continuum. The current growth in continuous, multimodal data over the disease course, ranging from vitals-monitoring in intensive care settings to wearable technologies, may enhance such an understanding but necessitates advanced computational tools. Our research group Computational Neurology aims to build links between data science, engineering and physics with neurology and patient care. We are developing and applying novel tools from physics and dynamical systems theory along with machine learning/artificial intelligence to better monitor, predict and prevent health deteriorations in epilepsy, intensive care and other neurological conditions. We hope that these insights will lead to a more quantitative, data-driven understanding of disease that ultimately affords more proactive treatment options.
Humboldt Universität zu Berlin (HU)
The Optobiology group combines biochemical, biophysical, molecular biological and bioinformatic methods with advanced imaging techniques to tackle questions dealing with different aspects of neuronal cell biology. Current projects explore roles of the microtubule and actin cytoskeleton as well as intracellular organelle trafficking in controlling the formation, stability and plasticity of synaptic contacts in health and disease.
German Center for Neurodegenerative Diseases (DZNE)
The Cellular Circuits of Memory group is focused on understanding how neuronal circuits in the hippocampal-associated brain regions are altered in normal aging as well as in memory pathologies. We use electrophysiological methods to investigate brain oscillations and single cell activity in animals while they perform different behavioral tasks. Taking advantage of transgenic mouse lines and genetic manipulations with viral vectors we try to understand how different cell types are involved in the formation of short and long-lasting memories. Our work is aimed at identifying altered neuronal circuits with the potential for manipulation in order to ameliorate or restore memory impairments in neurodegenerative diseases such as Alzheimer’s disease.
Dr. Noa Lipstein
Max-Planck-Institut für Experimentelle Medizin, Germany
Expected starting date: early 2021