FLIMMERBOX Study: Investigation of critical flicker frequency as a functional parameter of retinal function in patients with multiple sclerosis

This was a follow-up study involving the critical flicker frequency (CFF). CFF is the repetition frequency of a blinking light signal at which the temporal resolution ability of the eye can distinguish individual light signals. In other words, the CFF describes the frequency at which a person no longer perceives continuous light but rather a flickering signal. In this research project we investigated whether the CFF in MS patients differs from that of healthy individuals, and also whether the CFF in MS patients correlates with measurable damage to nerve fibers. There were three visits during this 1.5-year study, including a neurological examination, optical coherence tomography and an examination of the CFF. This study was open to patients with relapsing-remitting MS.

Study Director: Dr. Jan Dörr (WG Clinical Neuroimmunology, NCRC)

Course of the study: 10/2011 - 01/2016