TMS-MS Study: Repetitive deep transcranial magnetic stimulation in fatigue and depressiveness in multiple sclerosis

In addition to fatigue, depressiveness is also a very frequent symptom of MS, to date it has not been possible to treat either of these symptoms well with medication. During the past few years, so-called transcranial magnetic stimulation (TMS) has increasingly been used successfully for the treatment of depression. We examined the effect of a new kind of TMS method upon depression and fatigue in patients with MS. This study was oriented towards MS patients with fatigue syndrome and/or depression and was open for all forms of MS.

Study Director: Prof. Dr. Friedemann Paul (WG Clinical Neuroimmunology, NCRC, ECRC)

Course of the study: 02/2010 - 12/2011

Publications:
Gaede, G., M. Tiede, I. Lorenz, A. U. Brandt, C. Pfueller, J. Dorr, J. Bellmann-Strobl, S. K. Piper, Y. Roth, A. Zangen, S. Schippling, and F. Paul. "Safety and Preliminary Efficacy of Deep Transcranial Magnetic Stimulation in Ms-Related Fatigue." Neurol Neuroimmunol Neuroinflamm 5, no. 1 (Jan 2018): e423. Link