TRAINSTIM Study: Improvement of memory functions in older adults by training and non-invasive brain stimulation

The aim auf this project was the investigation of neuronal correlates and underlying mechanisms of non-invasive electrical stimulation in older adults of work and retirement age.Furthermore stimulation-induced effects on episodic memory functions were examined as well as the difference of these effect between age groups and compared to a young control group. We used in-vivo magnetic resonance (MR) spectroscopy and well as functional and structural connectivity assessments in order to probe associated neuronal correlates.

On the basis of the results, we wanted to develop a new training paradigm for working and episodic memory in order to examine the efficiency of a combined approach (computer-based training during stimulation) in a home-based context. The aim was to induce long-lasting effects not only on trained by also other tasks as well as activities of daily living.

Study director: Prof. Dr. med. Agnes Flöel (WG Cognitive Neurology, NCRC, Neurology CCM)

Course of the study:

  • Trainstim 1: 10/2015 - 12/2016
  • Trainstim 2: 03/2016 - 01/2017

The study is registered in the database:

Antonenko, D., M. Faxel, U. Grittner, M. Lavidor, and A. Floel. "Effects of Transcranial Alternating Current Stimulation on Cognitive Functions in Healthy Young and Older Adults." Neural Plast 2016 (2016): 4274127. Link

Antonenko, D., F. Schubert, F. Bohm, B. Ittermann, S. Aydin, D. Hayek, U. Grittner, and A. Floel. "Tdcs-Induced Modulation of Gaba Levels and Resting-State Functional Connectivity in Older Adults." J Neurosci 37, no. 15 (Apr 12 2017): 4065-73. Link